Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Volume 3 (2007), Issue 4 (April)

1. Chirality as a tool in nucleic acid recognition: principles and relevance in biotechnology and in medicinal chemistry.
   Chirality, 19(4): 269-94. [Abstract] [Full-text]
2. Design, synthesis, and biological evaluation of substituted-N-(thieno[2,3-b]pyridin-3-yl)-guanidines, N-(1H-pyrrolo[2,3-b]pyridin-3-yl)-guanidines, and N-(1H-indol-3-yl)-guanidines.
   Bioorg Med Chem, 15(9): 3248-65. [Abstract] [Full-text]
3. Design, synthesis, and evaluation of phenanthridine derivatives targeting the telomerase RNA/DNA heteroduplex.
   Bioorg Med Chem Lett, 17(8): 2267-73. [Abstract] [Full-text]
4. Predicting anti-HIV activity of PETT derivatives: CoMFA approach.
   Bioorg Med Chem Lett, 17(8): 2197-202. [Abstract] [Full-text]
5. 3D-QSAR studies with the aid of molecular docking for a series of non-steroidal FXR agonists.
   Bioorg Med Chem Lett, 17(8): 2156-60. [Abstract] [Full-text]
6. Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.
   Bioorg Med Chem Lett, 17(8): 2241-5. [Abstract] [Full-text]
7. Pharmacophore modeling and in silico screening for new KDR kinase inhibitors.
   Bioorg Med Chem Lett, 17(8): 2126-33. [Abstract] [Full-text]
8. Design of antimicrobial compounds based on peptide structures.
   Bioorg Med Chem Lett, 17(8): 2334-7. [Abstract] [Full-text]
9. Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists.
   Bioorg Med Chem Lett, 17(8): 2260-6. [Abstract] [Full-text]
10. Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides.
    Bioorg Med Chem Lett, 17(8): 2250-3. [Abstract] [Full-text]
11. Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.
    Bioorg Med Chem Lett, 17(8): 2305-9. [Abstract] [Full-text]
12. A novel method for assessing inhibition of ibuprofen chiral inversion and its application in drug discovery.
    Int J Pharm, 335(1): 63-9. [Abstract] [Full-text]
13. Protein design of a bacterially expressed HIV-1 gp41 fusion inhibitor.
    Biochemistry, 46(14): 4360-9. [Abstract] [Full-text]
14. pH-responsive aggregates from double hydrophilic block copolymers carrying zwitterionic groups. Encapsulation of antiparasitic compounds for the treatment of leishmaniasis.
    Langmuir, 23(8): 4214-24. [Abstract] [Full-text]
15. Swine models in the design of more effective medical countermeasures against organophosphorus poisoning.
    Toxicology, 233(1): 128-44. [Abstract] [Full-text]
16. Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors.
    Bioorg Med Chem Lett, 17(9): 2465-9. [Abstract] [Full-text]
17. 1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.
    Bioorg Med Chem Lett, 17(9): 2499-504. [Abstract] [Full-text]
18. Non-covalent complexes between bis-beta-carbolines and double-stranded DNA: A study by electrospray ionization FT-ICR mass spectrometry (I).
    Bioorg Med Chem Lett, 17(9): 2549-53. [Abstract] [Full-text]
19. Further studies of tyrosine surrogates in opioid receptor peptide ligands.
    Bioorg Med Chem Lett, 17(9): 2656-60. [Abstract] [Full-text]
20. Quercinol, an anti-inflammatory chromene from the wood-rotting fungus Daedalea quercina (Oak Mazegill).
    Bioorg Med Chem Lett, 17(9): 2558-60. [Abstract] [Full-text]
21. Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity.
    Bioorg Med Chem Lett, 17(9): 2421-4. [Abstract] [Full-text]
22. Affinity-based ranking of ligands for DPP-4 from mixtures.
    Bioorg Med Chem Lett, 17(9): 2404-7. [Abstract] [Full-text]
23. Methyl spongoate, a cytotoxic steroid from the Sanya soft coral Spongodes sp.
    Bioorg Med Chem Lett, 17(9): 2661-3. [Abstract] [Full-text]
24. Prediction of binding affinities to beta1 isoform of human thyroid hormone receptor by genetic algorithm and projection pursuit regression.
    Bioorg Med Chem Lett, 17(9): 2474-82. [Abstract] [Full-text]
25. beta-Alkylthio indolyl carbinols: potent nonsteroidal antiandrogens with oral efficacy in a prostate cancer model.
    Bioorg Med Chem Lett, 17(9): 2545-8. [Abstract] [Full-text]
26. Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin A.
    Bioorg Med Chem Lett, 17(9): 2459-64. [Abstract] [Full-text]
27. Identification of a series of tetrahydroisoquinoline derivatives as potential therapeutic agents for breast cancer.
    Bioorg Med Chem Lett, 17(9): 2581-9. [Abstract] [Full-text]
28. Synthesis and characterisation of a new pH-sensitive amphotericin B--poly(ethylene glycol)-b-poly(L-lysine) conjugate.
    Bioorg Med Chem Lett, 17(9): 2554-7. [Abstract] [Full-text]
29. Indole derivatives as potent inhibitors of 5-lipoxygenase: design, synthesis, biological evaluation, and molecular modeling.
    Bioorg Med Chem Lett, 17(9): 2414-20. [Abstract] [Full-text]
30. Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model.
    Bioorg Med Chem Lett, 17(9): 2425-9. [Abstract] [Full-text]
31. Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication.
    Bioorg Med Chem Lett, 17(9): 2452-5. [Abstract] [Full-text]
32. Asymmetric synthesis of novel alpha-amino acids with beta-branched side chains.
    Bioorg Med Chem Lett, 17(9): 2401-3. [Abstract] [Full-text]
33. Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus.
    Bioorg Med Chem Lett, 17(9): 2487-91. [Abstract] [Full-text]
34. Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors.
    Bioorg Med Chem Lett, 17(9): 2608-13. [Abstract] [Full-text]
35. Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors.
    Bioorg Med Chem Lett, 17(9): 2622-8. [Abstract] [Full-text]
36. N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors.
    Bioorg Med Chem Lett, 17(9): 2448-51. [Abstract] [Full-text]
37. ABC synthesis and antitumor activity of a series of Annonaceous acetogenin analogs with a threo, trans, threo, trans, threo-bis-tetrahydrofuran core unit.
    Bioorg Med Chem Lett, 17(9): 2434-7. [Abstract] [Full-text]
38. Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
    Bioorg Med Chem Lett, 17(9): 2535-9. [Abstract] [Full-text]
39. Synthesis and antifungal activity of 6-arylamino-phthalazine-5,8-diones and 6,7-bis(arylthio)-phthalazine-5,8-diones.
    Bioorg Med Chem Lett, 17(9): 2577-80. [Abstract] [Full-text]
40. 1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors.
    Bioorg Med Chem Lett, 17(9): 2523-6. [Abstract] [Full-text]
41. Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
    Bioorg Med Chem Lett, 17(9): 2483-6. [Abstract] [Full-text]
42. Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
    Bioorg Med Chem Lett, 17(9): 2570-6. [Abstract] [Full-text]
43. Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
    Bioorg Med Chem Lett, 17(9): 2603-7. [Abstract] [Full-text]
44. Synthesis and evaluation of diverse thio avarol derivatives as potential UVB photoprotective candidates.
    Bioorg Med Chem Lett, 17(9): 2561-5. [Abstract] [Full-text]
45. Synthesis and in vitro evaluation of tetrahydroisoquinolinyl benzamides as ligands for sigma receptors.
    Bioorg Med Chem Lett, 17(9): 2594-7. [Abstract] [Full-text]
46. M4 agonists/5HT7 antagonists with potential as antischizophrenic drugs: serominic compounds.
    Bioorg Med Chem Lett, 17(9): 2649-55. [Abstract] [Full-text]
47. Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome.
    Bioorg Med Chem Lett, 17(9): 2590-3. [Abstract] [Full-text]
48. Parallel synthesis and SAR study of novel oxa-steroids as potent and selective progesterone receptor antagonists.
    Bioorg Med Chem Lett, 17(9): 2531-4. [Abstract] [Full-text]
49. Synthesis and inhibition of cancer cell proliferation of (1,3')-bis-tetrahydroisoquinolines and piperazine systems.
    Bioorg Med Chem Lett, 17(9): 2598-602. [Abstract] [Full-text]
50. Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors.
    Bioorg Med Chem Lett, 17(9): 2540-4. [Abstract] [Full-text]
51. [d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor.
    Bioorg Med Chem Lett, 17(9): 2614-7. [Abstract] [Full-text]
52. [(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors.
    Bioorg Med Chem Lett, 17(9): 2618-21. [Abstract] [Full-text]
53. Prenyloxyphenylpropanoids as novel lead compounds for the selective inhibition of geranylgeranyl transferase I.
    Bioorg Med Chem Lett, 17(9): 2639-42. [Abstract] [Full-text]
54. 2,5-Disubstituted pyridines: the discovery of a novel series of 5-HT2A ligands.
    Bioorg Med Chem Lett, 17(9): 2643-8. [Abstract] [Full-text]
55. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold.
    Bioorg Med Chem Lett, 17(9): 2492-8. [Abstract] [Full-text]
56. Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
    Bioorg Med Chem Lett, 17(9): 2566-9. [Abstract] [Full-text]
57. 4-N-Methyl-N'-(2-dihydroxyboryl-benzyl)amino benzonitrile and its boronate analogue sensing saccharides and fluoride ion.
    Bioorg Med Chem Lett, 17(9): 2629-33. [Abstract] [Full-text]
58. Epoxygenase eicosanoids: synthesis of tetrahydrofuran-diol metabolites and their vasoactivity.
    Bioorg Med Chem Lett, 17(9): 2634-8. [Abstract] [Full-text]
59. A new method for testing synthetic drugs adulterated in herbal medicines based on infrared spectroscopy.
    Anal Chim Acta, 589(2): 200-7. [Abstract] [Full-text]
60. Medicinal plants used in Kirklareli Province (Turkey).
    J Ethnopharmacol, 111(2): 341-64. [Abstract] [Full-text]
61. Design of antisense oligonucleotides and short interfering RNA duplexes (siRNA) targeted to BCL6 mRNA: towards rational drug development for specific lymphoma subsets.
    Blood Cells Mol Dis, 38(3): 199-203. [Abstract] [Full-text]
62. Activity of essential oils from Brazilian medicinal plants on Escherichia coli.
    J Ethnopharmacol, 111(2): 197-201. [Abstract] [Full-text]
63. Prevention of hepatic oxidative injury by Xiao-Chen-Chi-Tang in mice.
    J Ethnopharmacol, 111(2): 232-9. [Abstract] [Full-text]
64. Plants of restricted use indicated by three cultures in Brazil (Caboclo-river dweller, Indian and Quilombola).
    J Ethnopharmacol, 111(2): 295-302. [Abstract] [Full-text]
65. Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats.
    J Ethnopharmacol, 111(2): 240-7. [Abstract] [Full-text]
66. Inhibitory effects of Hu-qi-yin on the bleomycin-induced pulmonary fibrosis in rats.
    J Ethnopharmacol, 111(2): 255-64. [Abstract] [Full-text]
67. QSAR study for the soybean 15-lipoxygenase inhibitory activity of organosulfur compounds derived from the essential oil of garlic.
    J Agric Food Chem, 55(8): 3096-103. [Abstract] [Full-text]
68. Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.
    J Med Chem, 50(8): 1876-85. [Abstract] [Full-text]
69. Designing active template molecules by combining computational de novo design and human chemist's expertise.
    J Med Chem, 50(8): 1925-32. [Abstract] [Full-text]
70. Effect of preparation method on compactability of paracetamol granules and agglomerates.
    Int J Pharm, 336(1): 148-58. [Abstract] [Full-text]
71. Novel pharmaceutical composition of bradykinin potentiating penta peptide with beta-cyclodextrin: physical-chemical characterization and anti-hypertensive evaluation.
    Int J Pharm, 336(1): 90-8. [Abstract] [Full-text]
72. Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material.
    Int J Pharm, 336(1): 1-11. [Abstract] [Full-text]
73. Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling.
    Int J Pharm, 336(1): 22-34. [Abstract] [Full-text]
74. Stacking complexation by nicotinamide: a useful way of enhancing drug solubility.
    Int J Pharm, 336(1): 35-41. [Abstract] [Full-text]
75. Foldamers as versatile frameworks for the design and evolution of function.
    Nat Chem Biol, 3(5): 252-62. [Abstract] [Full-text]
76. Positive aspects of negative design: simultaneous selection of specificity and interaction stability.
    Biochemistry, 46(16): 4804-14. [Abstract] [Full-text]
77. Anti-tumor and anti-invasive effects of diverse delta-alkyllactones: dependence on molecular side-chain length, action period and intracellular uptake.
    Life Sci, 80(20): 1851-5. [Abstract] [Full-text]
78. Using HapMap tools in pharmacogenomic discovery: the thiopurine methyltransferase polymorphism.
    Clin Pharmacol Ther, 81(5): 729-34. [Abstract] [Full-text]
79. Use of wavelet and fast Fourier transforms in pharmacodynamics.
    J Pharmacol Exp Ther, 321(2): 423-30. [Abstract] [Full-text]
80. Interaction of drug molecules with carrier systems as studied by parelectric spectroscopy and electron spin resonance.
    J Control Release, 119(1): 128-35. [Abstract] [Full-text]
81. Structure/reactivity relationships in the benzo[c]phenanthrene skeleton: stable ion and electrophilic substitution (nitration, bromination) study of substituted analogues, novel carbocations and substituted derivatives.
    J Org Chem, 72(9): 3232-41. [Abstract] [Full-text]
82. Bioprocessing of embryonic stem cells for drug discovery.
    Trends Biotechnol, 25(5): 224-30. [Abstract] [Full-text]
83. The role of pharmacogenetics in adjuvant treatment of non-small cell lung cancer.
    J Thorac Oncol, 2(5): S27-30. [Abstract] [Full-text]
84. Exploiting the defensive sugars of HIV-1 for drug and vaccine design.
    Nature, 446(7139): 1038-45. [Abstract] [Full-text]
85. Quantitative structure-activity relationship of peptides binding to the class II major histocompatibility complex molecule Aq associated with autoimmune arthritis.
    J Med Chem, 50(9): 2049-59. [Abstract] [Full-text]
86. A swift all-atom energy-based computational protocol to predict DNA-ligand binding affinity and DeltaTm.
    J Med Chem, 50(9): 2240-4. [Abstract] [Full-text]
87. Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.
    J Med Chem, 50(9): 2269-72. [Abstract] [Full-text]
88. Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.
    Mol Pharmacol, 71(5): 1288-97. [Abstract] [Full-text]
89. Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin.
    Org Biomol Chem, 5(9): 1427-36. [Abstract] [Full-text]
90. Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery.
    Expert Opin Ther Targets, 11(5): 695-705. [Abstract] [Full-text]
91. Mass spectrometry for enzyme assays and inhibitor screening: an emerging application in pharmaceutical research.
    Mass Spectrom Rev, 26(3): 324-39. [Abstract] [Full-text]
92. Heparanase: a target for drug discovery in cancer and inflammation.
    Br J Pharmacol, 151(1): 1-14. [Abstract] [Full-text]
93. Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery.
    J Chromatogr B Analyt Technol Biomed Life Sci, 850(1): 455-63. [Abstract] [Full-text]

© 2005-2008 Pharmacology Research Today. All Rights Reserved.