Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Building a pharmacological lexicon: small molecule discovery in academia.

Lazo JS, Brady LS, Dingledine R

Department of Pharmacology, Pittsburgh Molecular Library Screening Center, University of Pittsburgh, Biomedical Science Tower 3, Suite 10040, Pittsburgh, PA 15261-0001, USA. lazo@pitt.edu

Small molecules are powerful pharmacological tools to dissect biological events. There is now considerable interest in expanding efforts to identify and use small molecules targeting proteins encoded in the genomes of humans and pathogenic organisms. Integration of the principles of molecular pharmacology with contemporary high-throughput and high-content screening technologies is essential for the success of these discovery activities. We present some of the challenges and opportunities provided by the Molecular Library Screening Centers Network (MLSCN), which is a National Institutes of Health Roadmap Initiative.

Published 25 June 2007 in Mol Pharmacol, 72(1): 1-7.
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