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Handling of computational in vitro/in vivo correlation problems by Microsoft Excel: V. Predictive absorbability models.

Langenbucher F

BioVista LLC, Riehen, Switzerland. langenbucher.fr@bluewin.ch

This paper discusses Excel applications related to the prediction of drug absorbability from physicochemical constants. PHDISSOC provides a generalized model for pH profiles of electrolytic dissociation, water solubility, and partition coefficient. SKMODEL predicts drug absorbability, based on a log-log plot of water solubility and O/W partitioning; augmented by additional features such as electrolytic dissociation, melting point, and the dose administered. GIABS presents a mechanistic model of g.i. drug absorption. BIODATCO presents a database compiling relevant drug data to be used for quantitative predictions.

Published 4 July 2007 in Eur J Pharm Biopharm, 67(1): 293-9.
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