Pharmacology Research - Pharmacogenomics, Drug Development, New Medications

Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.


Pharmacology Research Today

Home

View Latest Issue

Information About Pharmacology

Books on Pharmacology

Advertising in Research Today

View Other Research Today Publications



Estimating the uncertainty associated with Widmark's equation as commonly applied in forensic toxicology.

Gullberg RG

Washington State Patrol, Breath Test Section, 811 East Roanoke, Seattle, WA 98102, United States. rod.gullberg@wsp.wa.gov

No computation is performed more frequently by forensic toxicologists than that involving Widmark's equation. The equation is employed to estimate either the number of drinks consumed or the corresponding blood or breath alcohol concentration. Despite the wide use of Widmark's equation, rarely is an uncertainty estimate also provided. Estimates from Widmark's equation involve at least seven uncertain random variables. Uncertainty estimates are presented that rely on methods of general error propagation compared to a method developed by Widmark. Assuming reasonable variable and uncertainty estimates, the error propagation method yielded for N=10.4 drinks, a combined uncertainty (standard deviation) of 1.3 drinks (CV=12.3%). Similarly, estimating the blood alcohol concentration yielded for 0.120 g/100 ml, an uncertainty of 0.0255 g/100 ml (CV=21.2%). Widmark's uncertainty method yielded 1.6 drinks (CV=15.4%). The derivation of Widmark's uncertainty estimate is also presented, showing that he considered only rho and beta to be uncertain. Widmark estimates for the number of drinks should include a 2CV estimate of approximately 25% while the blood alcohol concentration estimate should include a 2CV estimate of approximately 42%. Including valid estimates of uncertainty should enhance the legal admissibility and confidence for Widmark estimations.

Published 16 August 2007 in Forensic Sci Int, 172(1): 33-9.
Full-text of this article is available online (may require subscription).

Place a permanent text-link or advertisement here for just US$15.

© 2005-2008 Pharmacology Research Today. All Rights Reserved.



Pharmacology Research Today Archive:

Volume 1 (2005)
  Issue 1 (August)
  Issue 2 (September)
  Issue 3 (October)
  Issue 4 (November)
  Issue 5 (December)

Volume 2 (2006)
  Issue 1 (January)
  Issue 2 (February)
  Issue 3 (March)
  Issue 4 (April)
  Issue 5 (May)
  Issue 6 (June)
  Issue 7 (July)
  Issue 8 (August)
  Issue 9 (September)
  Issue 10 (October)
  Issue 11 (November)
  Issue 12 (December)

Volume 3 (2007)
  Issue 1 (January)
  Issue 2 (February)
  Issue 3 (March)
  Issue 4 (April)
  Issue 5 (May)
  Issue 6 (June)
  Issue 7 (July)
  Issue 8 (August)
  Issue 9 (September)
  Issue 10 (October)
  Issue 11 (November)
  Issue 12 (December)

Volume 4 (2008)
  Issue 1 (January)
  Issue 2 (February)
  Issue 3 (March)
  Issue 4 (April)
  Issue 5 (May)
  Issue 6 (June)
  Issue 7 (July)
  Issue 8 (August)



Pharmacology Books

PCAT Flashcards (REA) - PHARMACY COLLEGE ADMIN TEST (Flash Card Books)

PCAT Flashcards (REA) - PHARMACY COLLEGE ADMIN TEST (Flash Card Books)