Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Volume 4 (2008), Issue 10 (October)

1. Pharmacogenetics in drug discovery and development: a translational perspective.
   Nat Rev Drug Discov, 7(10): 807-17. [Abstract] [Full-text]
2. Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy.
   Br J Cancer, 99(7): 1050-5. [Abstract] [Full-text]
3. Bond-based 3D-chiral linear indices: theory and QSAR applications to central chirality codification.
   J Comput Chem, 29(15): 2500-12. [Abstract] [Full-text]
4. Structure-activity relationship anatomy by network-like similarity graphs and local structure-activity relationship indices.
   J Med Chem, 51(19): 6075-84. [Abstract] [Full-text]
5. Heteroarylnitrones as drugs for neurodegenerative diseases: synthesis, neuroprotective properties, and free radical scavenger properties.
   J Med Chem, 51(19): 6150-9. [Abstract] [Full-text]
6. Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.
   J Med Chem, 51(19): 6173-87. [Abstract] [Full-text]
7. Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
   J Med Chem, 51(19): 5932-42. [Abstract] [Full-text]
8. Identification of BRAF inhibitors through in silico screening.
   J Med Chem, 51(19): 6121-7. [Abstract] [Full-text]
9. Discovery of novel nitrobenzothiazole inhibitors for Mycobacterium tuberculosis ATP phosphoribosyl transferase (HisG) through virtual screening.
   J Med Chem, 51(19): 5984-92. [Abstract] [Full-text]
10. Flexible side chain models improve enrichment rates in in silico screening.
    J Med Chem, 51(19): 5919-31. [Abstract] [Full-text]
11. Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach.
    J Med Chem, 51(19): 6138-49. [Abstract] [Full-text]
12. Desirability-based multiobjective optimization for global QSAR studies: application to the design of novel NSAIDs with improved analgesic, antiinflammatory, and ulcerogenic profiles.
    J Comput Chem, 29(14): 2445-59. [Abstract] [Full-text]
13. Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.
    J Med Chem, 51(20): 6318-33. [Abstract] [Full-text]
14. Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.
    J Med Chem, 51(20): 6371-80. [Abstract] [Full-text]
15. Combining ligand-based pharmacophore modeling, quantitative structure-activity relationship analysis and in silico screening for the discovery of new potent hormone sensitive lipase inhibitors.
    J Med Chem, 51(20): 6478-94. [Abstract] [Full-text]
16. SIRTUIN 1: regulating the regulator.
    Biochem Biophys Res Commun, 376(2): 251-5. [Abstract] [Full-text]
17. Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target.
    Antiviral Res, 80(2): 94-101. [Abstract] [Full-text]
18. Chemical substructures that enrich for biological activity.
    Bioinformatics, 24(21): 2518-25. [Abstract] [Full-text]
19. Bioinformatic networks: molecular reticles for pinpointing pharmacological target selection.
    Clin Pharmacol Ther, 84(5): 543-5. [Abstract] [Full-text]
20. Antiemetic medications in children with presumed infectious gastroenteritis--pharmacoepidemiology in Europe and Northern America.
    J Pediatr, 153(5): 659-62, 662.e1-3. [Abstract] [Full-text]
21. System-oriented ecotoxicological research: which way to go?
    Sci Total Environ, 406(3): 530-6. [Abstract] [Full-text]
22. Animal pharming, two decades on.
    Transgenic Res, 17(6): 1025-33. [Abstract] [Full-text]
23. Genomic-scale prioritization of drug targets: the TDR Targets database.
    Nat Rev Drug Discov, 7(11): 900-7. [Abstract] [Full-text]

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