Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Volume 4 (2008), Issue 7 (July)

1. Creating and evaluating genetic tests predictive of drug response.
   Nat Rev Drug Discov, 7(7): 568-74. [Abstract] [Full-text]
2. Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting.
   J Med Chem, 51(13): 4030-7. [Abstract] [Full-text]
3. Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
   J Med Chem, 51(13): 3804-13. [Abstract] [Full-text]
4. Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist.
   J Med Chem, 51(13): 3692-5. [Abstract] [Full-text]
5. Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.
   J Med Chem, 51(13): 3814-24. [Abstract] [Full-text]
6. Design, synthesis, and testing of non-nephrotoxic desazadesferrithiocin polyether analogues.
   J Med Chem, 51(13): 3913-23. [Abstract] [Full-text]
7. Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets.
   Toxicol Sci, 104(2): 412-8. [Abstract] [Full-text]
8. How can we realize the promise of personalized antidepressant medicines?
   Nat Rev Neurosci, 9(8): 638-46. [Abstract] [Full-text]
9. An integrated platform of genomic assays reveals small-molecule bioactivities.
   Nat Chem Biol, 4(8): 498-506. [Abstract] [Full-text]
10. Sirtuins: novel targets for metabolic disease in drug development.
    Biochem Biophys Res Commun, 373(3): 341-4. [Abstract] [Full-text]
11. Simian immunodeficiency virus is susceptible to inhibition by carbohydrate-binding agents in a manner similar to that of HIV: implications for further preclinical drug development.
    Mol Pharmacol, 74(2): 330-7. [Abstract] [Full-text]
12. Considerations in using anticoagulant therapy in special patient populations.
    Am J Health Syst Pharm, 65(15): S13-21. [Abstract] [Full-text]
13. Sialyl alpha(2-->3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers.
    Bioorg Med Chem Lett, 18(15): 4405-8. [Abstract] [Full-text]
14. Refinement of histamine H3 ligands pharmacophore model leads to a new class of potent and selective naphthalene inverse agonists.
    Bioorg Med Chem Lett, 18(15): 4377-9. [Abstract] [Full-text]

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