Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Volume 4 (2008), Issue 8 (August)

1. The adult human brain in preclinical drug development.
   Nat Rev Drug Discov, 7(8): 659-66. [Abstract] [Full-text]
2. The molecular epidemiology of pain: a new discipline for drug discovery.
   Nat Rev Drug Discov, 7(8): 647-58. [Abstract] [Full-text]
3. A toxicogenomics approach for early assessment of potential non-genotoxic hepatocarcinogenicity of chemicals in rats.
   Toxicology, 250(1): 15-26. [Abstract] [Full-text]
4. Moving toward individualized cancer therapies.
   Clin Cancer Res, 14(15): 4682-4. [Abstract] [Full-text]
5. Design of a sialylglycopolymer with a chitosan backbone having efficient inhibitory activity against influenza virus infection.
   J Med Chem, 51(15): 4496-503. [Abstract] [Full-text]
6. Novel quinolinonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, and biological activities.
   J Med Chem, 51(15): 4744-50. [Abstract] [Full-text]
7. Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted acetates: synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators.
   J Med Chem, 51(15): 4715-23. [Abstract] [Full-text]
8. Chemical proteomics-based drug design: target and antitarget fishing with a catechol-rhodanine privileged scaffold for NAD(P)(H) binding proteins.
   J Med Chem, 51(15): 4571-80. [Abstract] [Full-text]
9. Identification and validation of human DNA ligase inhibitors using computer-aided drug design.
   J Med Chem, 51(15): 4553-62. [Abstract] [Full-text]
10. Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.
    J Med Chem, 51(15): 4685-98. [Abstract] [Full-text]
11. Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors.
    J Med Chem, 51(15): 4609-19. [Abstract] [Full-text]
12. Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins.
    J Med Chem, 51(15): 4660-71. [Abstract] [Full-text]
13. Agreement between self-reported data on medicine use and prescription records vary according to method of analysis and therapeutic group.
    J Clin Epidemiol, 61(9): 919-24. [Abstract] [Full-text]
14. Toxicogenomics -- a novel opportunity to probe lupus susceptibility and pathogenesis.
    Int Immunopharmacol, 8(10): 1330-7. [Abstract] [Full-text]
15. Computational study of histamine H3-receptor antagonist with support vector machines and three dimension quantitative structure activity relationship methods.
    Anal Chim Acta, 624(2): 203-9. [Abstract] [Full-text]
16. Peter B. Dews and pharmacological studies on behavior.
    J Pharmacol Exp Ther, 326(3): 683-90. [Abstract] [Full-text]
17. Individual genomes instead of race for personalized medicine.
    Clin Pharmacol Ther, 84(3): 306-9. [Abstract] [Full-text]
18. Finding the right research question: quality science depends on quality careers.
    Clin Pharmacol Ther, 84(3): 427-9. [Abstract] [Full-text]
19. The role of ethnicity in variability in response to drugs: focus on clinical pharmacology studies.
    Clin Pharmacol Ther, 84(3): 417-23. [Abstract] [Full-text]
20. Ethics at the intersection of pharmacoethnicity.
    Clin Pharmacol Ther, 84(3): 424-6. [Abstract] [Full-text]
21. Pharmacogenetic pathway analysis of irinotecan.
    Clin Pharmacol Ther, 84(3): 393-402. [Abstract] [Full-text]
22. Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.
    Clin Pharmacol Ther, 84(3): 326-31. [Abstract] [Full-text]
23. CoMFA based de novo design of pyrrolidine carboxamides as inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis.
    J Mol Model, 14(10): 923-35. [Abstract] [Full-text]
24. Computational discovery of novel low micromolar human pregnane X receptor antagonists.
    Mol Pharmacol, 74(3): 662-72. [Abstract] [Full-text]
25. Quantitative structure carcinogenicity relationship for detecting structural alerts in nitroso-compounds: species: rat; sex: male; route of administration: water.
    Toxicol Appl Pharmacol, 231(2): 197-207. [Abstract] [Full-text]
26. Novel anti-HIV peptides containing multiple copies of artificially designed heptad repeat motifs.
    Biochem Biophys Res Commun, 374(4): 767-72. [Abstract] [Full-text]
27. Herbogenomics: from traditional Chinese medicine to novel therapeutics.
    Exp Biol Med (Maywood), 233(9): 1059-65. [Abstract] [Full-text]

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