Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Volume 5 (2009), Issue 2 (February)

1. Benefits of the maximum tolerated dose (MTD) and maximum tolerated concentration (MTC) concept in aquatic toxicology.
   Aquat Toxicol, 91(3): 197-202. [Abstract] [Full-text]
2. VSDMIP: virtual screening data management on an integrated platform.
   J Comput Aided Mol Des, 23(3): 171-84. [Abstract] [Full-text]
3. An improved scoring function for suboptimal polar ligand complexes.
   J Comput Aided Mol Des, 23(3): 143-52. [Abstract] [Full-text]
4. Calculation of molecular lipophilicity: State-of-the-art and comparison of log P methods on more than 96,000 compounds.
   J Pharm Sci, 98(3): 861-93. [Abstract] [Full-text]
5. The discovery of HNPC-A3066: a novel strobilurin acaricide.
   Pest Manag Sci, 65(3): 229-34. [Abstract] [Full-text]
6. Drug incompatibility chemistry.
   Am J Health Syst Pharm, 66(4): 348-57. [Abstract] [Full-text]
7. Pharmaceuticals in the environment: good practice in predicting acute ecotoxicological effects.
   Toxicol Lett, 185(2): 85-101. [Abstract] [Full-text]
8. Binding estimation after refinement, a new automated procedure for the refinement and rescoring of docked ligands in virtual screening.
   Chem Biol Drug Des, 73(3): 283-6. [Abstract] [Full-text]
9. Methods for computer-aided chemical biology. Part 4: selectivity searching for ion channel ligands and mapping of molecular fragments as selectivity markers.
   Chem Biol Drug Des, 73(3): 273-82. [Abstract] [Full-text]
10. A lifetime passion for micronucleus cytome assays--reflections from Down Under.
    Mutat Res, 681(2): 111-7. [Abstract] [Full-text]
11. Improving prediction of chemical carcinogenicity by considering multiple mechanisms and applying toxicogenomic approaches.
    Mutat Res, 681(2): 230-40. [Abstract] [Full-text]
12. Aligning antimicrobial drug discovery with complex and redundant host-pathogen interactions.
    Cell Host Microbe, 5(2): 114-22. [Abstract] [Full-text]
13. A simple in vitro assay for assessing the reactivity of nitrile containing compounds.
    Bioorg Med Chem Lett, 19(4): 1136-8. [Abstract] [Full-text]
14. Screening we can believe in.
    Nat Chem Biol, 5(3): 127. [Abstract] [Full-text]
15. Overview: Evaluation of metabolism-based drug toxicity in drug development.
    Chem Biol Interact, 179(1): 1-3. [Abstract] [Full-text]
16. Leaching of contaminants from untreated pine bark in a batch study: chemical analysis and ecotoxicological evaluation.
    J Hazard Mater, 163(2): 1096-100. [Abstract] [Full-text]
17. Ecotoxicity tests in the environmental analysis of wastewater treatment plants: case study in Portugal.
    J Hazard Mater, 163(2): 665-70. [Abstract] [Full-text]
18. Potential natural product discovery from microbes through a diversity-guided computational framework.
    Appl Microbiol Biotechnol, 82(3): 579-86. [Abstract] [Full-text]
19. Biomarker discovery: validation and decision-making in product development.
    Sex Transm Dis, 36(3): S76-80. [Abstract] [Full-text]
20. Estimation of the warfarin dose with clinical and pharmacogenetic data.
    N Engl J Med, 360(8): 753-64. [Abstract] [Full-text]
21. Translational medicine for stroke drug discovery: the pharmaceutical industry perspective.
    Stroke, 40(3): S121-5. [Abstract] [Full-text]
22. From simple toxicological models to prediction of toxic effects in time.
    Ecotoxicology, 18(3): 343-54. [Abstract] [Full-text]
23. The influence of lead discovery strategies on the properties of drug candidates.
    Nat Rev Drug Discov, 8(3): 203-12. [Abstract] [Full-text]
24. The 'atypicality' of antipsychotics: a concept re-examined and re-defined.
    Nat Rev Drug Discov, 8(3): 197-202. [Abstract] [Full-text]
25. Hybrid scoring and classification approaches to predict human pregnane X receptor activators.
    Pharm Res, 26(4): 1001-11. [Abstract] [Full-text]
26. Development of a new predictive model for interactions with human cytochrome P450 2A6 using pharmacophore ensemble/support vector machine (PhE/SVM) approach.
    Pharm Res, 26(4): 987-1000. [Abstract] [Full-text]
27. Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins.
    Pharm Res, 26(4): 936-45. [Abstract] [Full-text]

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