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Fluorinated carbohydrates as lectin ligands: versatile sensors in 19F-detected saturation transfer difference NMR spectroscopy.

Diercks T, Ribeiro JP, Cañada FJ, André S, Jiménez-Barbero J, Gabius HJ

NMR facility, CiC bioGUNE, Parque Tecnológico de Bizkaia, Ed. 800, 48160 Derio, Spain.

As a novel approach for studying carbohydrate-lectin interactions spectroscopically, we combine the resolution and specificity of (19)F-detected NMR spectroscopy with the sensitivity of the saturation transfer difference (STD) technique. The resulting background-free (19)F-STD spectra open a promising perspective for broad application with medical relevance, for example, in drug discovery.

Published 1 June 2009 in Chemistry, 15(23): 5666-8.
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