Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Volume 5 (2009), Issue 8 (August)

1. Building disease-specific drug-protein connectivity maps from molecular interaction networks and PubMed abstracts.
   PLoS Comput Biol, 5(7): e1000450. [Abstract] [Full-text]
2. Characterization of the contents of ascending colon to which drugs are exposed after oral administration to healthy adults.
   Pharm Res, 26(9): 2141-51. [Abstract] [Full-text]
3. Semiparametric distributions with estimated shape parameters.
   Pharm Res, 26(9): 2174-85. [Abstract] [Full-text]
4. Computational mapping tools for drug discovery.
   Drug Discov Today, 14(15): 767-75. [Abstract] [Full-text]
5. Can Drosophila melanogaster represent a model system for the detection of reproductive adverse drug reactions?
   Drug Discov Today, 14(15): 761-6. [Abstract] [Full-text]
6. New tools for functional genomic analysis.
   Drug Discov Today, 14(15): 754-60. [Abstract] [Full-text]
7. Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward?
   Drug Discov Today, 14(15): 804-11. [Abstract] [Full-text]
8. Strategic groups in the biopharmaceutical industry: implications for performance.
   Drug Discov Today, 14(15): 726-30. [Abstract] [Full-text]
9. Drug discovery chemistry: a primer for the non-specialist.
   Drug Discov Today, 14(15): 731-44. [Abstract] [Full-text]
10. Blind docking of 260 protein-ligand complexes with EADock 2.0.
    J Comput Chem, 30(13): 2021-30. [Abstract] [Full-text]
11. Current status of amorphous formulation and other special dosage forms as formulations for early clinical phases.
    J Pharm Sci, 98(9): 2875-85. [Abstract] [Full-text]
12. Chemical approaches to nuclear receptors in metabolism.
    Sci Signal, 2(82): mr5. [Abstract] [Full-text]
13. KKKKPLFGLFFGLF: a cationic peptide designed to exert antibacterial activity.
    Peptides, 30(9): 1608-12. [Abstract] [Full-text]
14. Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics.
    J Clin Endocrinol Metab, 94(8): 3072-84. [Abstract] [Full-text]
15. Looking forward in pharmaceutical process chemistry.
    Science, 325(5941): 701-4. [Abstract] [Full-text]
16. Discovery: an interactive resource for the rational selection and comparison of putative drug target proteins in malaria.
    Malar J, 8: 178. [Abstract] [Full-text]
17. Relevance of the aryl hydrocarbon receptor (AhR) for clinical toxicology.
    Clin Toxicol (Phila), 47(7): 632-42. [Abstract] [Full-text]
18. ADMET rules of thumb II: A comparison of the effects of common substituents on a range of ADMET parameters.
    Bioorg Med Chem, 17(16): 5906-19. [Abstract] [Full-text]
19. Weight-of-evidence evaluation in environmental assessment: review of qualitative and quantitative approaches.
    Sci Total Environ, 407(19): 5199-205. [Abstract] [Full-text]
20. Overview of emerging pharmacotherapy in chronic heart failure.
    Expert Opin Pharmacother, 10(13): 2055-74. [Abstract] [Full-text]
21. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening.
    Biochemistry, 48(32): 7732-45. [Abstract] [Full-text]
22. Design of functional metalloproteins.
    Nature, 460(7257): 855-62. [Abstract] [Full-text]
23. When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D study.
    Neuropsychopharmacology, 34(10): 2227-36. [Abstract] [Full-text]
24. Recent advances in computer-aided drug design.
    Brief Bioinform, 10(5): 579-91. [Abstract] [Full-text]
25. Target profiling of small molecules by chemical proteomics.
    Nat Chem Biol, 5(9): 616-24. [Abstract] [Full-text]
26. Taking the chemical out of chemical genetics.
    Nat Chem Biol, 5(9): 609-10. [Abstract] [Full-text]
27. Design, synthesis and selection of DNA-encoded small-molecule libraries.
    Nat Chem Biol, 5(9): 647-54. [Abstract] [Full-text]
28. Finding new drug targets for the treatment of migraine attacks.
    Cephalalgia, 29(9): 909-20. [Abstract] [Full-text]
29. Dynamic template-assisted strategies in fragment-based drug discovery.
    Trends Biotechnol, 27(9): 512-21. [Abstract] [Full-text]
30. Novel opportunities for computational biology and sociology in drug discovery.
    Trends Biotechnol, 27(9): 531-40. [Abstract] [Full-text]
31. Cationic liposomes as carriers for aerosolized formulations of an anionic drug: safety and efficacy study.
    Eur J Pharm Sci, 38(2): 165-71. [Abstract] [Full-text]
32. Analysis and use of fragment-occurrence data in similarity-based virtual screening.
    J Comput Aided Mol Des, 23(9): 655-68. [Abstract] [Full-text]
33. The neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking.
    Prog Neurobiol, 89(1): 18-45. [Abstract] [Full-text]
34. Robust optimization of scoring functions for a target class.
    J Comput Aided Mol Des, 23(9): 633-44. [Abstract] [Full-text]
35. Dendrimers as therapeutic agents: a systematic review.
    J Pharm Pharmacol, 61(8): 989-1003. [Abstract] [Full-text]
36. Controlling the cost of innovative cancer therapeutics.
    Nat Rev Clin Oncol, 6(9): 550-2. [Abstract] [Full-text]
37. Pharmacogenomics of antidepressant drugs.
    Pharmacol Ther, 124(1): 57-73. [Abstract] [Full-text]
38. Eco-toxic effects of sulfadiazine sodium, sulfamonomethoxine sodium and enrofloxacin on wheat, Chinese cabbage and tomato.
    Ecotoxicology, 18(7): 878-85. [Abstract] [Full-text]
39. Wildlife toxicology: biomarkers of genotoxic exposures at a hazardous waste site.
    Ecotoxicology, 18(7): 886-98. [Abstract] [Full-text]
40. Standardizing acute toxicity data for use in ecotoxicology models: influence of test type, life stage, and concentration reporting.
    Ecotoxicology, 18(7): 918-28. [Abstract] [Full-text]
41. History of wildlife toxicology.
    Ecotoxicology, 18(7): 773-83. [Abstract] [Full-text]
42. Detectability of fifteen aquatic micro/mesocosms.
    Ecotoxicology, 18(7): 838-45. [Abstract] [Full-text]
43. Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin".
    Org Lett, 11(17): 3970-3. [Abstract] [Full-text]
44. Pharmacogenetics of solid tumors: directed therapy in breast, lung, and colorectal cancer: a paper from the 2008 william beaumont hospital symposium on molecular pathology.
    J Mol Diagn, 11(5): 381-9. [Abstract] [Full-text]
45. Herbal medicines in the management of urolithiasis: alternative or complementary?
    Planta Med, 75(10): 1095-103. [Abstract] [Full-text]
46. Antibiotics for emerging pathogens.
    Science, 325(5944): 1089-93. [Abstract] [Full-text]
47. Recipe for uncovering the bioactive components in herbal medicine.
    Anal Chem, 81(17): 7217-25. [Abstract] [Full-text]

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