Pharmacology Research Today is a free monthly online journal that collates and summarizes the latest research about Pharmacology, including details on pharmacogenomics, drug development, new medications.

Volume 5 (2009), Issue 9 (September)

1. Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.
   J Med Chem, 52(15): 4694-715. [Abstract] [Full-text]
2. Lowering industry firewalls: pre-competitive informatics initiatives in drug discovery.
   Nat Rev Drug Discov, 8(9): 701-8. [Abstract] [Full-text]
3. N-O-isopropyl sulfonamido-based hydroxamates: design, synthesis and biological evaluation of selective matrix metalloproteinase-13 inhibitors as potential therapeutic agents for osteoarthritis.
   J Med Chem, 52(15): 4757-73. [Abstract] [Full-text]
4. Carbonic anhydrase-encoded dynamic constitutional libraries: toward the discovery of isozyme-specific inhibitors.
   J Med Chem, 52(15): 4853-9. [Abstract] [Full-text]
5. 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation.
   J Med Chem, 52(15): 4743-56. [Abstract] [Full-text]
6. The history of antiretrovirals: key discoveries over the past 25 years.
   Rev Med Virol, 19(5): 287-99. [Abstract] [Full-text]
7. Bioaccessibility, bioavailability and ecotoxicity of pentachlorophenol in compost amended soils.
   Chemosphere, 77(1): 80-6. [Abstract] [Full-text]
8. From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal.
   Nature, 461(7260): 74-7. [Abstract] [Full-text]
9. Design and synthesis of androgen receptor antagonists with bulky side chains for overcoming antiandrogen resistance.
   J Med Chem, 52(17): 5546-50. [Abstract] [Full-text]
10. Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
    J Med Chem, 52(17): 5295-8. [Abstract] [Full-text]
11. Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase.
    J Med Chem, 52(17): 5531-45. [Abstract] [Full-text]
12. A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.
    J Med Chem, 52(17): 5330-43. [Abstract] [Full-text]
13. Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGFA) gene and antidepressant treatment response in major depressive disorder.
    Psychiatry Res, 169(2): 113-7. [Abstract] [Full-text]
14. Toxicology has to use opportunities given by Bologna reform of higher education.
    Toxicol Lett, 190(2): 116-22. [Abstract] [Full-text]
15. Molecular docking study of A(3) adenosine receptor antagonists and pharmacophore-based drug design.
    Neurochem Int, 55(7): 637-42. [Abstract] [Full-text]
16. 'OnePoint'--combining OneNote and SharePoint to facilitate knowledge transfer.
    Drug Discov Today, 14(17): 845-50. [Abstract] [Full-text]
17. Biotech acquisitions by big pharma: why and what is next.
    Drug Discov Today, 14(17): 818-21. [Abstract] [Full-text]
18. siRNAs: their potential as therapeutic agents--Part I. Designing of siRNAs.
    Drug Discov Today, 14(17): 851-8. [Abstract] [Full-text]
19. A note on statistical analysis of organ weights in non-clinical toxicological studies.
    Toxicol Appl Pharmacol, 240(1): 117-22. [Abstract] [Full-text]
20. Criteria for the selection of single nucleotide polymorphisms in pathway pharmacogenetics: TNF inhibitors as a case study.
    Drug Discov Today, 14(17): 837-44. [Abstract] [Full-text]
21. Conciliating binding efficiency and polypharmacology.
    Trends Pharmacol Sci, 30(9): 470-4. [Abstract] [Full-text]
22. Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity.
    J Clin Oncol, 27(26): 4406-12. [Abstract] [Full-text]
23. Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs.
    Biochem J, 423(1): 61-9. [Abstract] [Full-text]
24. Pharmacogenetics in cardiovascular antithrombotic therapy.
    J Am Coll Cardiol, 54(12): 1041-57. [Abstract] [Full-text]
25. Structure-based discovery of low molecular weight compounds that stimulate neurite outgrowth and substitute for nerve growth factor.
    J Neurochem, 110(6): 1876-84. [Abstract] [Full-text]
26. Making sense of antisense in antibiotic drug discovery.
    Cell Host Microbe, 6(3): 197-8. [Abstract] [Full-text]
27. Interactions between parasitism and biological responses in zebra mussels (Dreissena polymorpha): Importance in ecotoxicological studies.
    Environ Res, 109(7): 843-50. [Abstract] [Full-text]
28. Organizing for innovation: towards successful translational research.
    Trends Biotechnol, 27(10): 558-61. [Abstract] [Full-text]
29. A multispecies-monitoring study about bioaccumulation of mercury in Iranian birds (Khuzestan to Persian Gulf): Effect of taxonomic affiliation and trophic level.
    Environ Res, 109(7): 830-6. [Abstract] [Full-text]
30. Assessing the risk of lead exposure for the conservation of the endangered Pyrenean bearded vulture (Gypaetus barbatus) population.
    Environ Res, 109(7): 837-42. [Abstract] [Full-text]
31. A pipeline of therapies for cystic fibrosis.
    Semin Respir Crit Care Med, 30(5): 611-26. [Abstract] [Full-text]
32. Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity.
    J Med Chem, 52(18): 5603-11. [Abstract] [Full-text]
33. Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification.
    J Med Chem, 52(18): 5649-61. [Abstract] [Full-text]
34. Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.
    J Med Chem, 52(18): 5619-25. [Abstract] [Full-text]
35. Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.
    J Med Chem, 52(18): 5748-52. [Abstract] [Full-text]
36. Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nat Chem Biol, 5(10): 765-71. [Abstract] [Full-text]
37. Translating inflammatory bowel disease research into clinical medicine.
    Immunity, 31(3): 357-61. [Abstract] [Full-text]
38. Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity.
    J Pharmacol Exp Ther, 331(1): 277-86. [Abstract] [Full-text]
39. Shuffling multivariate adaptive regression splines and adaptive neuro-fuzzy inference system as tools for QSAR study of SARS inhibitors.
    J Pharm Biomed Anal, 50(5): 853-60. [Abstract] [Full-text]
40. Characterization of azacytidine/poly(L-lactic) acid particles prepared by supercritical antisolvent precipitation.
    J Pharm Biomed Anal, 50(5): 847-52. [Abstract] [Full-text]
41. A sensitive LC-MS/MS method to quantify loureirin B in rat plasma with application to preclinical pharmacokinetic studies.
    J Pharm Biomed Anal, 50(5): 983-6. [Abstract] [Full-text]
42. A stability-indicating HPLC assay with diode array detection for the determination of a benzylpenicillin prodrug in aqueous solutions.
    J Pharm Biomed Anal, 50(5): 841-6. [Abstract] [Full-text]
43. Development and validation of a stability-indicating RP-LC method for famciclovir.
    J Pharm Biomed Anal, 50(5): 797-802. [Abstract] [Full-text]
44. Validated bioanalytical method for the quantification of RGB-286638, a novel multi-targeted protein kinase inhibitor, in human plasma and urine by liquid chromatography/tandem triple-quadrupole mass spectrometry.
    J Pharm Biomed Anal, 50(5): 977-82. [Abstract] [Full-text]
45. Screening for metabolites of acarviostatin family aminooligosaccharides in rats using ultraperformance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
    J Pharm Biomed Anal, 50(5): 917-23. [Abstract] [Full-text]
46. Determination of free amino acid content in Radix Pseudostellariae using near infrared (NIR) spectroscopy and different multivariate calibrations.
    J Pharm Biomed Anal, 50(5): 803-8. [Abstract] [Full-text]
47. Simultaneous determination of senecionine, adonifoline and their metabolites in rat serum by UPLC-ESIMS and its application in pharmacokinetic studies.
    J Pharm Biomed Anal, 50(5): 1070-4. [Abstract] [Full-text]
48. Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves.
    J Pharm Biomed Anal, 50(5): 1060-4. [Abstract] [Full-text]
49. Determination of inorganic pharmaceutical counterions using hydrophilic interaction chromatography coupled with a Corona CAD detector.
    J Pharm Biomed Anal, 50(5): 809-14. [Abstract] [Full-text]
50. LC-UV and LC-MS evaluation of stress degradation behaviour of tenatoprazole.
    J Pharm Biomed Anal, 50(5): 787-93. [Abstract] [Full-text]
51. Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection.
    J Pharm Biomed Anal, 50(5): 932-8. [Abstract] [Full-text]
52. Reduction of matrix interferences by the combination of chaotropic salt and DMSO in a broadly applicable target-based ELISA for pharmacokinetic studies of therapeutic monoclonal antibodies.
    J Pharm Biomed Anal, 50(5): 924-31. [Abstract] [Full-text]
53. Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit.
    J Pharm Biomed Anal, 50(5): 695-702. [Abstract] [Full-text]
54. Use of a quality-by-design approach to justify removal of the HPLC weight % assay from routine API stability testing protocols.
    J Pharm Biomed Anal, 50(5): 794-6. [Abstract] [Full-text]
55. Development and validation of a stability indicating LC method for the assay and related substances determination of exemestane, an aromatase inhibitor.
    J Pharm Biomed Anal, 50(5): 746-52. [Abstract] [Full-text]
56. Simultaneous determination of risperidone and 9-hydroxyrisperidone enantiomers in human blood plasma by liquid chromatography with electrochemical detection.
    J Pharm Biomed Anal, 50(5): 905-10. [Abstract] [Full-text]
57. Development of HPLC fingerprints for Mallotus species extracts and evaluation of the peaks responsible for their antioxidant activity.
    J Pharm Biomed Anal, 50(5): 753-63. [Abstract] [Full-text]
58. Characterization of aspartame-cyclodextrin complexation.
    J Pharm Biomed Anal, 50(5): 737-45. [Abstract] [Full-text]
59. NMR analysis, protonation equilibria and decomposition kinetics of tolperisone.
    J Pharm Biomed Anal, 50(5): 718-23. [Abstract] [Full-text]
60. Identification of gentamicin impurities by liquid chromatography tandem mass spectrometry.
    J Pharm Biomed Anal, 50(5): 1037-43. [Abstract] [Full-text]
61. Determination of low ppm levels of dimethyl sulfate in an aqueous soluble API intermediate using liquid-liquid extraction and GC-MS.
    J Pharm Biomed Anal, 50(5): 1054-9. [Abstract] [Full-text]
62. Profiling of levoamphetamine and related substances in dexamphetamine sulfate by capillary electrophoresis.
    J Pharm Biomed Anal, 50(5): 1050-3. [Abstract] [Full-text]
63. Development and validation of LC-MS/MS method for the determination of cyproheptadine in several pharmaceutical syrup formulations.
    J Pharm Biomed Anal, 50(5): 1044-9. [Abstract] [Full-text]
64. Isolation and structural elucidation of dapoxetine as an adulterant in a health supplement used for sexual performance enhancement.
    J Pharm Biomed Anal, 50(5): 724-8. [Abstract] [Full-text]
65. A novel strategy for reducing phospholipids-based matrix effect in LC-ESI-MS bioanalysis by means of HybridSPE.
    J Pharm Biomed Anal, 50(5): 867-71. [Abstract] [Full-text]
66. The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.
    J Pharm Biomed Anal, 50(5): 861-6. [Abstract] [Full-text]
67. Physical-chemical characterization of binary and ternary systems of ketoprofen with cyclodextrins and phospholipids.
    J Pharm Biomed Anal, 50(5): 683-9. [Abstract] [Full-text]
68. Pharmacologic interventions for stroke: looking beyond the thrombolysis time window into the penumbra with biomarkers, not a stopwatch.
    Stroke, 40(10): e558-63. [Abstract] [Full-text]

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